“How 3C Patch® generates a living cell product that actively responds to the wound environment” was presented by Rasmus Lundquist, CSO of Reapplix at the Innovations in Wound Healing Conference, December 11-13, 2020. Rasmus has an MSc. in Biology and Immunology from Copenhagen University and a graduate certificate in Biodesign from Stanford University.
What is the incidence of diabetic foot ulcers?
Diabetic foot ulcers are a severe complication of diabetes. There are an estimated 463 mio. diabetics worldwide, of which approximately 31 Mio are in the US.
The lifetime incidence of foot ulcers suggests that approximately 19 – 34% of persons with diabetes are likely to develop a foot ulcer. Furthermore, only 30% of the diabetic foot ulcers heal in 12 weeks, even with specialized outpatient wound care.
The non-healing diabetic foot ulcers can be predicted by following area change at 4 weeks: if less than 50% of the wound area changes in 4 weeks, only 2-9% of the diabetic foot ulcers will heal in 12 weeks.
How can 3C Patch® help in the management of non-healing diabetic foot ulcers?
In non-healing diabetic foot ulcers, there can be a sub-optimal inflammatory response in the wound, this, coupled with potential biofilm formation, can lead to the healing process being stalled.
The approach of the 3C Patch® System is to take the key components in the patient’s blood and introduce them into the wound bed.
The procedure comprises 3 steps:
- 18 ml of the patient’s blood is drawn into a 3C Patch® Device by venipuncture
- The filled 3C Patch® Device is placed into the 3CP® Centrifuge
- After 15-20 minutes, the 3C Patch® is generated and transferred to the wound
In-vitro studies show that 3C Patch® contains living cells that are able to engulf bacteria. In terms of the composition of the 3C Patch®, the studies show that a high number of cells are retained: 55% of the neutrophils, 77% of the Lymphocytes, 85% of the Monocytes, and 98% of the platelets.
By applying the 3C Patch®, which contains all the inflammatory components: the leukocytes that are known to fight the infection, as well as growth factors and cytokines, to the wound, can help the process move into the proliferation phase, and thus potentially re-starting the healing process.
See the full presentation below
The presentation was part of a Scientific Symposium held during the Innovations in Wound Healing Conference, December 2020, and is addressed to researchers and practitioners interested in the wound care field. If you have patients suffering from non-healing diabetic foot ulcers this information might be of educational interest to you.
The presentation first went live on the 12th of December 2020, it lasts for approximately 12 minutes and touches on the common causes of non-healing diabetic foot ulcers, the science and technology behind 3C Patch® and how the living cells in the 3C Patch® respond to the wound environment.
See the full presentation below and feel free to contact us if you have additional questions about the 3C Patch® Technology.